Saturday, November 10, 2007

Scientific authoring and publishing in the new age of multimedia: A Better Idea?

I would like you to indulge me for a moment and consider the following item from a recent entry in the Amazon Daily blog and forwarded here via my Google Reader account. Not only is it interesting from a digital photography standpoint, but it has implications on my vocation as an analytical chemist, but more about that after you read the article.

via Google Reader:

via Amazon Daily by Amazon Daily on 11/6/07

I learned about digital photography metadata from the FBI. They didn't give me a course or anything; they sent out a news release years ago that terrorists may be sending messages encoded into pictures on the Internet. As far as I know, your dgital camera isn't serving Al Qaeda's ends, but it did let me to discover that there's a whole world of information in a JPEG beyond the pictures you see.

You probably know what metadata is -- we use it all the time now, whether putting track names on an MP3 or looking up a library book by its Dewey Decimal number. You may even have used it on your photos, tagging a shot of the beach as "vacation." But it can be staggering to learn how much information there actually is.

Example: This is a JPEG:

But this is the information inside. The shutter speed, the aperture, user-added tags, even latitiude and longitude, they're all in there. Don't worry, though -- people can't find out your address from your online photos unless you want them to, or unless you're careless. There are two groups of metadata important to understand -- EXIF and IPTC. Broadly speaking, EXIF is what is captured on the image at the time you shot it, and IPTC are all the user-added comments afterward. Your EXIF knows what the camera was doing -- when the picture was taken, how fast the shutter went, what lens you used, etc., but it doesn't know that you were taking a picture of your aunt. That's for you to add.

What good is metadata? It's hard to even scratch the surface of the possibilities, but two major benefits are organization and improving your craft by figuring out how other people took photos you enjoy. The benefits for organization are obvious to anyone who's ever tried to sort through a basement full of negatives. The different between sorting through a box that says "Mid-80s" and being able to zoom in on photos you took on April 12 is palpable. If you take advantage of programs that can add metadata -- from free programs like Apple's iPhoto to professional software like Adobe Lightroom -- you can be as organized as you want. Maybe you want to note all of the people in the photos you take. Maybe you're into color and want to track which photos were dominantly red, and which were dominantly green. Maybe you want to track all the photos you took in Hawaii -- whatever you want, the notes affix themselves to the photo, so you'll have them wherever you store it.

But there's more. This is the Web 2.0 age, a time of unprecedented sharing. You don't have to ask a photographer "Hey, what camera did you use to take this?" If you can see the EXIF, you'll know, along with what focal length, ISO, shutter speed and aperture he or she used to make the photo look the way it does. Sites like Flickr or Picasa Web Albums have the EXIF available for public viewing on every photo (at the photographer's discretion), and they can be a great course in learning exactly what sorts of images these parameters can create. Sure, you can know intellectually that a long focal length lens plus a wide aperture equals a shallow range of focus, but isn't it easier to see it?

Here's the EXIF for this image.What does it tell us? The shallow focus comes from the combination of focal length (85mm), aperture (f/1.4) and distance (not shown, but about 15-20 feet). The shutter speed had to be 1/100th to freeze motion (and that was pushing it; faster would have been better if possible), and the ISO had to be bumped up to 1600 to allow that shutter speed to happen indoors. You can learn a lot about a photographer's choices from looking through EXIF.

So what can't you learn? In advanced photography, actually snapping the shutter is the least difficult part -- it's getting to the spot where the picture happens that matters. Either that's a physical journey to exotic locales, the sidelines of the big game, waiting for the perfect sunset, setting up studio lights, or simply getting your subject to react to you in an attractive way. EXIF won't help you there.

Take this photo:

This was taken at 102mm at f/13 and ISO 100. We can learn a few things about the photographer's choices from there -- it's attractively proportioned because of a long focal length, the small aperture and low ISO meant standard room light would be totally black, so this was lit by bright flashes, but we can't go out and recreate this photo just knowing those settings. And that's just a studio shot -- EXIF certainly isn't going to get you a gorgeous shot of the Hindu Kush mountains. Because of that, I hope that photographers are more free with letting their EXIF show on Web-based photos so beginners and intermediate students can learn valuable things about the mechanics of a shot. It's a great way to learn Photography 101, especially for the visually-oriented people who become photographers, but it's not going to cost the pros their jobs.


--Ryan Brenizer

Things you can do from here:



Now consider...

In measurement science, analytical chemistry in particular, data are "converted" into pictures in at least two major ways. First, and most obvious, is they are presented as images called photographs and videos. Second, and perhaps less directly obvious are the pictures of data that we scientists would normally call spectra. In both cases, one can imagine the same metadata as described in this article "enhancing" the photographs and videos taken. It could include all instrumental parameters needed to obtain the image. Moreover, standard operating procedures (SOP's), sample preparation, chain of custody, and every datum necessary to establish the pedigree of the sample studied could be directly embedded with the data of the spectra. Indeed, the entire analyst report could be part of the photograph, video, or spectrum.

Today, we consider such data as parts of reports. The emphasis is on the written word and each written report may contain or reference several images, videos, or spectra that enhance an author's point within a specific passage of a report. My questions are... can we do better and is this approach always the best?

Images, whether they are photographs, videos, or spectra make a powerful impact on the viewer. Indeed, the truism that a picture states a thousand words is unrefuted. Why then, as scientists, do we cling to burying such powerful media in written reports. I think there is a better way.

Consider Amazon again for a moment. When you search for a book, you are presented an emphasis on the image of the book, the title and, lately, hovering over images of books bring a list of links leading you to more information, much of it text but, potentially, some of it more imagery. Amazon does not bury the image of the book within the bounds of prose that might describe the book.

So how would such work in science? Imagine that instead of the National Transportation Safety Committee (NTSC) publishing a long report on an accident that includes a few pictures, it chose one image that highlights a particular aspect of the investigation, or the entire investigation, creates links and metadata within those images that reference and cross-reference items in the report. The table of contents could be a series of images followed by one line of text and the reader would quickly connect with the contents through the powerful imagery being presented.

Many other examples can be imagined. Databases emphasizing image based content already exist with the inclusion of chemical structures, spectra thumbnails, etc. Scientific journals are starting to include images as part of their web-based table of contents, but does this go far enough in encouraging authors to emphasize image-based authoring? Show a spectrum and embed the report rather that the other way around. Relative to publishers, research labs in the chemical and petrochemical industry are lagging significantly in this regard with little capability today on content management, knowledge management, and multimedia publishing systems to enable these approaches. As multimedia publication becomes cheaper, ubiquitous, and more flexible, should we consider the traditional scientific publication format passe?

I hope to have time in the future to create some specific examples emphasizing some of the advantages that I envision such a approach to have.

Thursday, November 01, 2007

Resolving Oligomers from Fully Grown Polymers with IMS-MS

Sarah Trimpin, Manolo Plasencia, Dragan Isailovic, and David E. Clemmer*

Department of Chemistry, Indiana University, Bloomington, Indiana 47405

Anal. Chem., 79 (21), 7965 -7974, 2007. 10.1021/ac071575i S0003-2700(07)01575-2 Web Release Date: September 22, 2007 Copyright © 2007 American Chemical Society

Link to Abstract

Ion mobility and mass spectrometry techniques, combined with electrospray ionization, have been used to examine distributions of poly(ethylene glycols) (PEG) with average molecular masses of 6550 and 17900 Da. The analysis provides information about the polymer size distributions as well as smaller oligomers existing over a wide range of charge states and sizes
(i.e., [HO(CH2CH2O)xH + nCs]n+, where x ranges from 21 to 151 and n = 2 to 11 for the 6550 Da sample; and, x ranges from 21 to 362 and n = 2 to 23 for the 17 900 Da sample).

Liquid NMR probes: Oh so many choices

Vendors offer a wide variety of probes with applications that include synthetic chemistry, protein structure determination, and metabolomics. This product review in Analytical Chemistry reviews some of the choices.

http://pubs.acs.org/subscribe/journals/ancham/79/i21/pdf/1107prodrev.pdf


Analyzing fermented beverages by microCE

RESEARCH PROFILES


Analyzing fermented beverages by microCE

In this issue of Analytical Chemistry
(pp 8162-8169), Richard Mathies and
colleagues at the University of California
Berkeley describe their efforts to
develop a simple point-of-consumption
testing platform by adapting technologies
that they first developed to look for
signs of life on Mars.

Thursday, October 11, 2007

2007 Nobel Prize in Chemistry

The 2007 Nobel Prize in Chemistry has been awarded to Gerhard Ertl (Germany) "for his studies of chemical processes on solid surfaces". Dr. Ertl developed methodology to measure and analyze surface reactions under high-vacuum to prevent the contamination that could invalidate the measurements. Ertl used these techniques to elucidate the specifics of the Haber-Bosch process. The Haber-Bosch process is used to produce plant fertilizer. He also studied the oxidation of carbon monoxide on platinum, which is used to clean automobile emissions

Wednesday, October 03, 2007

FW: WCS Oct 4 meeting reminder

Thursday, October 4, 2007 MEETING

WESTCHESTER CHEMICAL SOCIETY

Fingerprinting Molecules by Proton NMR Spectroscopy

Speaker:


Prof. Abhijit Mitra
Dept. of Chemistry of Biochemistry
College of Mount St. Vincent
Riverdale, NY

Understanding π-π stacking plays an important role in determining the properties and behaviors of biomolecules and their interactions with drugs and proteins. We have recently shown that π-π stacking interaction can be studied by hitherto unknown concentration dependent chemical shift changes for a wide variety of heteroaromatic compounds in 1H-NMR spectroscopy.

Thursday, October 4, 2007

Times:

Refreshments 5:30 PM
Lecture 6:15 PM

Place

Polytechnic University
Westchester Graduate Center
40 Saw Mill River Road
Hawthorn, NY

Directions at HTTP://www.poly.edu/west/environment/directions/

Wednesday, August 29, 2007

Airport Chemistry

The following article

Subject : Airport Chemistry
Abstract: For all the screening that has become a standard part of air travel, existing methods can't expose every hint of criminal activity ...
Link : http://www.chemistry.org/portal/a/c/s/1/feature_ent.html?id=c373e9079e2c2c0e8f6a17245d830100

has a broken link. I am reproducing the article in its entirety (03 October 2007) until I can find the new link to it, if there is one.


Airport Chemistry

Margaret_Hill
www.chemistry.org



It’s that time of year when thousands of Americans endure long lines at airport security checkpoints as they travel for the holidays. But for all the screening that has become a standard part of air travel, existing methods can’t expose every hint of criminal activity that passes through. Fortunately, chemical detection methods are advancing in ways that should improve the situation.
At Purdue University, for example, R. Graham Cooks’ research group has worked out a rapid and reliable method for detecting trace quantities of compounds lying on surfaces. Its ease of use and quick turnaround time should make it ideal for airport security personnel to scan the exteriors of luggage, packages, and clothing for traces of nefarious chemical compounds such as explosives or drugs.

The method involves mass spectrometry, a chemical identification tool known for its sensitivity and accuracy. Despite these attributes, however, mass spectral methods have not been applied to testing situations such as those needed at airport security sites. A major problem has been the time-consuming sample preparation needed for these techniques. Another factor is the need for vacuum conditions within the ionization chamber of the spectrometer. And finally, to house all of their working parts, mass spectrometers have tended to be quite large instruments not built for portability.

By making several key modifications in instrument design and sampling technique, Cooks’ group has bypassed these limitations. The team adapted electrospray ionization (ESI) technology to engineer a sampling “wand” that dislodges samples from surfaces, ionizes them in the presence of air, and then passes them along to a mass spectrometer for analysis, all within a matter of seconds. Cooks’ group also condensed the equipment down to backpack-size. The method, known as desorption electrospray ionization, or DESI, makes it possible to take mass spectral analyses into totally new environments.

Because the method also can be applied to a broad variety of compounds, it is versatile and has a broad potential of use. When Cooks published this work last year in Science (306, 471–473), he wrote that it “seems particularly promising for forensic and public-safety applications, including analysis of dried blood, detection of explosives, and monitoring of chemical warfare agents.”

Since then, to demonstrate how their technique might be applied to a real-world example, the group evaluated the method’s capability of detecting and identifying a number of explosives. The results were published in the November 5, 2005, issue of Analytical Chemistry (77, 6755N-6764).

Testing their method with four modern explosive compounds, the researchers found limits of detection ranging from 100 picograms down to 0.01 picograms (1 picogram is one-trillionth of a gram), depending on the compound and the surface it was tested on (e.g., metal, paper, glass, plastic, and polymer examples). The picogram capabilities of method produced accurate identification of trace quantities of all four explosives.

The researchers also studied mixtures—military-made plastic mixtures such as Composition C-4 and mixtures put together to simulate post-blast types of situations. Not only did the method sort out and identify the compositions of all of the mixtures, it did so for residue quantities of those mixtures. In one test, for example, an experimenter pressed his thumb to a sample of C-4 and then repeatedly pressed down on a series of glass slides with the same thumb. Even after five sequential transfers, the residue provided sufficient material that could be positively identified.

In addition to its obvious application to security screening and forensic investigations, this method will no doubt have significant impact on environmental testing. It represents a timely and valuable addition to the arsenal of detection methods currently in use.


This article first appeared on November 21, 2005.

Copyright © 2007 American Chemical Society.
All Rights Reserved

Thursday, August 23, 2007

FW: Watch "Nanowires and Nanocrystals for Nanotechnology"

Nanowires and Nanocrystals for Nanotechnology

42 min 15 sec - Sep 12, 2006
Average rating:   (126 ratings)
Description: Google Tech Talks September 12, 2006 Yi Cui is an assistant professor in the Materials Science and Engineering Department at Stanford University. He is a recipient of the Technology Review World Top 100 Young Innovator Award. He received his PhD degree from Harvard University working with Prof. Charles Lieber. He received his B.S. degree from Univ of Science and Technology of China. ABSTRACT Nanowires and nanocrystals represent important nanomaterials with one-dimensional and zero-dimensional morphology, respectively. Here I will give an overview on the research about how these nanomaterials impact the critical applications in faster transistors, smaller nonvolatile memory devices, efficient solar energy conversion, high-energy battery and nanobiotechnology.

Want to see more cool videos?
Go to video.google.com/

Think you have an even cooler video?
Add it at video.google.com/videouploadform

If you're having trouble watching the video, try copying the following URL into your browser:
http://video.google.com/videoplay?docid=6571968052542741458&subtitle=on&pr=goog-sl

Saturday, August 18, 2007

Chemical Metrology in the Americas

The following article

Subject : Chemical Metrology in the Americas
Abstract: The Inter-American Metrology System is a broad agreement among national metrology institutes from all 34 member nations of the Orga...
Link : http://www.chemistry.org/portal/a/c/s/1/feature_tea.html?id=c373e9079e2d2f368f6a17245d830100 has a broken link. I am reproducing the article in its entirety (03 October 2007) until I can find the new link to it, if there is one.


Chemical Metrology in the Americas


Bradley D. Miller
www.chemistry.org


The Inter-American Metrology System (SIM) is a broad agreement among national metrology institutes (NMIs) from all 34 member nations of the Organization of American States (OAS). Organized in five subregions (NORAMET, CARIMET, CAMET, ANDIMET, and SURAMET), SIM was created to promote international, particularly Inter-American, and regional cooperation in metrology.
An area of specific concern to SIM as a region is chemical metrology. Chemical metrology involves the development of methods, capabilities and facilities to address chemical measurement traceability, uncertainty analysis, standards availability, documentary standards development and distribution, accreditation needs and requirements, benchmarking criteria, and interlaboratory comparisons.

The SIM technical working group dedicated to chemical metrology emphasizes communication and information sharing in its activities. To address the unique needs of all 34 countries within SIM, whose capabilities in chemical metrology span a very broad range, the leadership of the technical working group has initially focused SIM Chemical Metrology activities on training and capability assessment. This has been accomplished through (1) Outreach and Awareness Activities within the ANDIMET, CAMET, CARIMET, and SURAMET subregions; and (2) Chemical Measurement Proficiency Assessment Comparison Studies.

The Chemical Metrology Awareness Seminars are targeted to governmental decision makers and representatives from NMIs within the particular subregion. Since 2003 these seminars have been conducted in Jamaica, Venezuela, Costa Rica, Argentina, Peru, and Trinidad & Tobago. Content typically addresses topics on chemical metrology and its impact on trade and quality of life and the current worldwide infrastructure on facilitating chemical measurement traceability and comparability. There are also lectures—localized to the region—on clinical diagnostics, environmental quality, and food safety and nutrition.

The workshops on Critical Evaluation of Comparison Results are open to NMIs from the host subregion plus all participants in any particular comparison study in which an NMI receives and analyzes a test sample and then works with peer NMIs to determine best practices moving toward equivalency in interlaboratory comparisons. Past SIM chemistry proficiency assessment studies have focused on trace elements in water, pH, automotive exhaust emissions, cholesterol serum, ethanol in aqueous matrix, water quality–electrolytic conductivity, and toxic metals in seafood.

Willie E. May director the Chemical Science and Technology Laboratory of the National Institute of Standards and Technology (CSTL/NIST), serves as chair of the SIM Chemical Metrology Working Group, and his efforts focus on building and supporting a chemical metrological structure in the Americas to ensure equity in the marketplace, facilitate international trade, ensure uniformity of measurements, and improve the quality of life for all citizens of the region.


This article first appeared on November 21, 2005.


Copyright © 2007 American Chemical Society.
All Rights Reserved.

Monday, July 09, 2007

Increasing the speed of LC analysis describes how to get "more separation in a shorter run."


Steve Miller

Uncertainty in modern spectrophotometers is "an up-to-date view of UV–Vis molecular absorption instruments and measurements."

Javier Galbán, Susana de Marcos, Isabel Sanz, Carlos Ubide, Juan Zuriarrain

Tuesday, May 08, 2007

Mechanoluminescence event yields novel emissions, reactions

"You may, when in the dark frighten simple people only by chewing lumps of sugar, and, in the meantime, keeping your mouth open, which will appear to them as if full of fire," Father Giambattista Beccaria wrote in "A Treatise Upon Artificial Electricity," in 1753. Mechanoluminescence is the light generated when a crystal, such as sugar or quartz, is fractured by grinding, cleaving or via other mechanical means. Sir Francis Bacon wrote about this phenomenon as early as 1605.

Researchers at the University of Illinois report here extensive atomic and molecular spectral emission not previously seen in a mechanoluminescence event. The findings, which appear online this month in the Journal of the American Chemical Society, also include the first report of gas phase chemical reactions resulting from a mechanoluminescence event.

Thursday, May 03, 2007

The Ultrachron

Analyzing Tiny Time Crystals with the Ultrachron: The Ultrachron is an electron microprobe designed to analyze grains of monazite, a mineral that contains rare earth metals cerium, lanthanum, and neodymium. In some monazite crystals, uranium and thorium are also present. Because these latter two elements undergo radioactive decay in a predictable time pattern, their presence turns monazite into a tiny timekeeper.

More information about the Ultrachron and its research applications is available at: Ultra-Chron Project.

Wednesday, May 02, 2007

Spectroscopy: 2007 Salary Survey

The 2007 Salary Survey published in Spectroscopy Magazine

http://www.spectroscopymag.com/spectroscopy/content/contentDetail.jsp?id=412205

Staff editor Brian Johnson takes a look at this year's salaries and trends in employment for spectroscopists.

________________________________________________________________
This information comes to you courtesy of spectroscopyonline.com

Catalyst characterization

This article describes work at Shell to characterize catalysists at more realistic conditions of temperature and pressure.

http://www.rsc.org/Publishing/ChemTech/Volume/2007/06/industry_laboratory_gap.asp

Ionic liquids' Etch a Sketch surprise

Secondary ion mass spectrometry (SIMS) employs an ion beam (e.g., gallium ions) allowing the chemical analysis of surfaces. When such was directed toward ionic liquids, the result fires electrons out of the liquid's surface, creating a dark pattern that can not only be written and read, but also erased and rewritten. Read all about it here.

Monday, April 30, 2007

The Nanostructure Problem

Nanostructures can pose big measurement problems:
While many methods exist for probing the atomic structure on the nanoscale, no single technique can provide a unique structural solution. This paper calls for a coordinated effort by researchers to develop a coherent strategy for a comprehensive solution of the “nanostructure problem” using inputs from multiple experimental methods and theory.

###

* S.J.L. Billinge and I. Levin. The problem with determining atomic structure at the nanoscale. Science, 316: 5823, April 27, 2007.

Thursday, April 26, 2007

Today's Updates

Researchers 'see' catalyst molecules at work: Researchers have for the first time 'watched' in real time single molecules of catalyst participating in a reaction at a solid-liquid interface


Instant insight: Nanocrystals as sensors: This article address the paradox around quantum dots... the properties of the quantum dots for imaging and labeling applications are achieved by making the quantum dot impervious to its environment. How can quantum dots be sensitive to their environment if they are encased within the cocoon of a passivating overcoat?


Nanoscale scales: Scientists at the Massachusetts Institute of Technology (MIT) in the US have designed a device able to accurately weigh to within one femtogram (one thousandth of a millionth of a millionth or 10-15 of a gram) single nanoparticles within a liquid.


Water's surface is acidic: Pure, neutral water has an acid skin. This striking notion has now been confirmed by calculations and tests.The finding could be significant for a number of disciplines. In atmospheric chemistry, many important chemical reactions between trace gases take place at the surface of water droplets in clouds where pH is an essential factor and low pH could also affect the rates of carbon dioxide absorption at the ocean surface. In molecular biology the effect might be reproduced where water comes into contact with water-repelling (hydrophobic) parts of proteins, changing the acid-base chemistry.


Determination of Size and Concentration of Gold Nanoparticles from UV-Vis Spectra: Work by Wolfgang Haiss et al. provide a simple and fast method to determine size and concentration of nanoparticles. Their work, published in Analytical Chemistry describe the theoretical analysis on the dependence of the optical properties of spherical gold nanoparticles on particle size and wavelength using multipole scattering theory, where the complex refractive index of gold was corrected for the effect of a reduced mean free path of the conduction electrons in small particles. The theoretical results were compared to experimental data; gold nanoparticles in the size range of 5 to 100 nm were synthesized and characterized with TEM and UV-vis. Excellent agreement was found, showing that the data produced here can be used to determine both size and concentration of gold nanoparticles directly from UV-Vis spectra. Equations for this purpose are derived, and the precision of various methods is discussed.

Wednesday, April 25, 2007

NMR Tutorial

Nuclear Magnetic Resonance (NMR) is a powerful chemical analysis tool and is related to Magnetic Resonance Imaging (MRI) by is basis in the same fundemental physical phenomena. I recently came across an intersting tutorial site on the web for NMR. Check it out here

Scanning magnetoresistance microscopy

Scanning magnetoresistance microscopy of atom chips
Results highlight the use of scanning MR microscopy as a convenient and powerful technique for precisely characterizing the magnetic fields produced near the surface of atom chips.

Tuesday, April 24, 2007

News: IBM researchers push MRI imaging to nanoscale

Researchers at IBM’s Almaden Research Center have developed magnetic resonance imaging (MRI) techniques to visualize nanoscale objects. The new techniques are a major milestone in the quest to build a microscope that could "see" individual atoms in three dimensions.

Click here to go to the IBM news website

Friday, April 20, 2007

Analytical Sciences Digital Library

The Analytical Sciences Digital Libary (ASDL) is supported by the NSDL program of the National Science Foundation and represents a searchable topical library with a large selection of links on A-Z topics relating to analytical chemistry and measurement science. I have already checked out a couple of the links there and have been impressed. Included are links to tutorials, amination, and resources on a whole array of techniques and methodologies. I cretainly recommend that you check it out.

Sorting Out Lead Levels

Concern over the presence of the lead in various sources of drinking water result in an analytical chemistry challenge, because of the need to avoid contamination of the vessels and apparatus. Inadequate attention to this problem has resulted in conflicting reports of the lead concentrations measured in bottled waters. One solution is described by Shotyk and Krachler and applies clean-room procedures and high-sensitivity detection technology that was developed to gauge the nanogram-per-liter concentrations of lead present in polar ice to the measurement of lead levels in commercially available bottled waters from across the world and artesian flow sources in southern Ontario, Canada. The measured concentrations were below the 10microgram/liter level considered hazardous. However, glass bottles appeared to leach lead over time, roughly doubling concentrations from ~100 to ~200 ng/liter in water stored in them over 6 months. Concentrations measured in plastic bottles ranged from <1 to 761 ng/liter. However, other organic materials unanalyzed in this study may be leaching out of the plastic. The artesian sources exhibited a narrowly ranged lead concentration having a median of 5.1 ng/liter.

This abstract is based on that presented in the Editor's Choice list of ScienceMag.org: here. Full details were published in Environ. Sci. Technol. 41, 10.1021/es062964h (2007).

Thursday, April 19, 2007

Separations Science: Molecular-beam methods and novel electrodes simplify analysis of mixtures

Separations Science
Molecular-beam methods and novel electrodes simplify analysis of mixtures by Mitch Jacoby describes the work of a team that recently developed and tested an advanced-generation GC-MS interface device that transports sample compounds eluting from a GC column to a mass spectrometer by way of a supersonic molecular beam. This methodology promises to circumvent two particularly intractable problems in GC-MS analysis.


  1. The relatively small range of volatile and thermally stable compounds that are amenable to analysis; and
  2. The relatively weak molecular ion observed from many analytes.

For the entire Chemical and Engineering News article, click here .

The Daily Pennsylvanian - Penn prof, Nobel laureate dies at 79

During my term on the Nichols Medal Jury (a medal honoring chemists that is award by the New York Section of the American Chemical Society), our 2002 awardee was Dr. Alan MacDiarmid. Dr. MacDiarmid had already been awarded the Nobel Prize; however, he was very honored to recieve the Nichols Medal. I remember my meeting him with great fondness. He caried the gold medal Nobel Prize in his pocket and enjoyed offering people the opportunity to hold it saying, "I have created more Nobel Prize holders than any other recipient in history." His passing was in February and I only learned of it today. The news may be late, but to me it is sad. Below is a link to the story...

The Daily Pennsylvanian Email Edition

Penn prof, Nobel laureate dies at 79

Chemistry professor Alan MacDiarmid, one of three recipients of the 2000 Nobel Prize in Chemistry, died yesterday afternoon. He was 79. MacDiarmid had been suffering from Myelodysplastic Syndrome, a disease that affects the bone marrow and blood, for the past four years.

* The sender's identity has not been verified.

Friday, April 13, 2007

Diffraction and scattering -- the solution to what's in solution


Researchers at the Department of Energy's Argonne National Laboratory and the University of Notre Dame have successfully applied X-ray scattering techniques to determine how dissolved metal ions interact in solution. Click here for details.
Credit: Argonne National Laboratory

A Peek Inside*

The semiconductor industry routinely fabricates device structures with feature sizes smaller than 100 nm. With millions of components crowded onto each chip and complex circuitry arrayed in three dimensions, methods to test the structures for defects--preferably nondestructively and with high throughput--become challenging. Techniques for imaging the subsurface structures tend to face a tradeoff between resolution and contrast. The probe light must have a relatively long wavelength (usually in the infrared) in order to penetrate through several millimeters of silicon in the wafer and be absorbed by the active layers of the device; however, this wavelength requirement has generally restricted lateral resolution. Ramsay et al. combine immersion lens imaging with two-photon absorption microscopy to improve both the lateral resolution and the absorption contrast, thereby providing a technique for the high-resolution three-dimensional imaging of the subsurface structures in silicon chip circuitry. -- ISO

Appl. Phys. Lett. 90, 131101 (2007).

*the above text is taken directly from - this link: http://www.sciencemag.org/content/vol316/issue5822/twil.dtl?rss=1#316/5822/174b

Raman Probes Shape Up

A method in which a probe pulse is delayed and has its shape optimized so to minimize the nonresonant background contributions may enable many practical applications of Raman spectroscopy previously determined impracticle. Raman spectrscopy is a technique that can provide a wealth of information about molecular vibrations and provide fingerprint-like signatures for identification, but even when signal strength is boosted by coherently exciting the vibrations with laser pulses, a fluctuating background signal hindersin sensing. For details on this new development, click here

Thursday, April 12, 2007

Water Identified in Extrasolar Planet Atmosphere

Water has been identified in the atmosphere of an extrasolar planet for the first time using a combination of previously published Hubble Space Telescope measurements and new theoretical models. This result was recently accepted for publication in the Astrophysical Journal (http://lanl.arxiv.org/abs/0704.1114). For the details, click here

Friday, March 30, 2007

Infrared Spectrum and Structure of Thorimine (HNThH2)

Laser-ablated thorium atoms react with ammonia to form thorimine (NHThH2), the first actinide imine to be reported. For details, click here

Friday, March 23, 2007

Fluorescence, Phosphorence and Photoluminescence

Fluorescence and phosphorence are types of photoluminescence. When the bonds of the luminescent molecules absorb some of the energy to which they are exposed, part of it can be released as visible light. These processes are important to analytical chemists. To learn a bit about them, check out this site on About.com: Click Here.

Thursday, March 15, 2007

Phateful Phate of Phthalates

Phthalates have been widely used for more than 50 years. The phthalate family of chemicals is used in a variety of products from cosmetics, shampoos, soaps, lotions, lubricants, paint, pesticides, and plastics. Phthalates soften plastic tubing, PVC, and are also used in the coating of some timed-release medicines. Exposure to phthalates already has been connected to reproductive problems. Now, for the first time, is linked to abdominal obesity and insulin resistance in adult males, according to a study by the University of Rochester Medical Center. Sounds like a chemical analysis opportunity to me!

Click here to learn more


Source University of Rochester Medical Center and the Science Blog

Tuesday, March 13, 2007

Fourier Transform Deconvolution of Noisy Signals

I have some long time interest in approaches to deconvoluting noisy signals with Fourier Transforms. The problem with the approach is the division step that often results in the creation of noise rather than extraction of the underlying signal. Today, I came across a paper entitled "Fourier Transform deconvolution of noisy signals and partial Savitzky-Golay filtering in the transformed side" that I found intriguing. Check it out at this link.

Mathamatical Details on the Savitzky-Golay Filter

The Savitzky-Golay Filter is an often occurring data processing step in instrumental analytical chemistry. The following link presents a pretty straightforward explanation on the mathematical background involved. You will need knowledge of linear algebra...

http://www.vias.org/tmdatanaleng/cc_filter_savgol_math.html

A more detailed explanation with some sample code and spectral results are on this link:
http://www.ma.utexas.edu/documentation/nr/bookcpdf/c14-8.pdf

Friday, March 09, 2007

How to Make Red Cabbage pH Indicator: Acid-Base Chemistry

For those of you who want to help the public understand some basics around analytical chemistry, I came across an interesting page in About.com. Below is an abstract to peak your interest. The link includes a lab you might want to give to the experimentalists you know as an acid test (every pun intended).

Red cabbage contains a pigment molecule called flavin. Very acidic solutions will turn it a red color. Basic solutions appear in greenish-yellow. Intermediate, neutral solutions result in a purplish color. It is possible to determine the pH of a solution based on the color it turns the pigments in red cabbage juice, because the color of the juice changes in response to changes in its hydrogen ion concentration. pH is the -log[H+]. Acids will donate hydrogen ions in an aqueous (water) solution and have a low pH (pH <> 7). This concentration change, in turn, affects the structure of the pigment resulting in a different absorption spectrum (i.e., different color).

Find out more at this link.

Thursday, March 08, 2007

Scanning-tunnelling spectra of cuprates

The following abstract is based on this link at Nature an International Weekly Journal of Science

Nature 446, E3-E4 (8 March 2007) doi:10.1038/nature05709; Published online 7 March 2007
Jungseek Hwang1, Thomas Timusk1,2 and Jules P. Carbotte1,2

Arising from: J. Lee et al. Nature 442, 546–550 (2006)

The study of bosonic modes that couple to the charge carriers is a key element in understanding superconductivity. Using atomic-resolution scanning-tunnelling microscopy (STM) to extract the spectrum of these modes in the high-temperature superconductor Bi2Sr2CaCu2O8+, Lee et al.1 infer a role for lattice modes (phonons). The lattice mode seen by Lee et al.1 is concluded to be irrelevant to superconductivity and is due to inelastic tunnelling through the insulating oxide layer5.

Department of Physics and Astronomy, McMaster University, Hamilton, Ontario L8S 4M1, Canada
Canadian Institute of Advanced Research, Toronto, Ontario M5G 1Z8, Canada
Correspondence to: Thomas Timusk1,2 Email: timusk@mcmaster.ca

Tuesday, March 06, 2007

EnvironmentalChemistry.com article on CO2 and Global Warming

CO2 Pollution and Global Warming (EnvironmentalChemistry.com) - Why is carbon dioxide, a life sustaining compound, considered pollution?

Star Trek 'Tricorder' For Chemical Analysis

Scientists Invent Real-life 'Tricorder' For Chemical Analysis. Purdue University researchers have created a handheld sensing system its creators liken to Star Trek's "tricorder" used to analyze the chemical components of alien worlds. But the system could have down-to-earth applications, such as testing foods for dangerous bacterial contaminants including salmonella, which was recently found in a popular brand of peanut butter. - from ScienceDaily

Today's Updates

Terahertz electrical and optical characteristics of double-walled carbon nanotubes and their comparison with single-walled carbon nanotubes
Engineering Village


In Research Profile: Reliable dispensing of attoliter volumes of fluid, Stephen Jacobson has been hashing out some of the basic infrastructure of this nanorealm. An initial step “is to see how well things from the microfluidic regime scale to the nanofluidic regime,” Jacobson says. “What can you transfer from microfluidics to nanofluidics, and does it work?”
from Analytical Chemistry A-Pages


In this month's "Analytical Currents" from Analytical Chemistry A-Pages appears
Microfabricated Fabry–Pérot interferometer with nanochannels

As nanochannels become thinner than ~20
nm, optical microscopy can’t distinguish
between gas and liquid phases because
the differences in the optical path length
become negligible. To overcome these challenges, Jan
Eijkel and colleagues at the University of
Twente (The Netherlands) designed a
miniaturized Fabry–Pérot interferometer
with micromachined channels that had silver
mirrors embedded in both channel
walls.

Monday, March 05, 2007

Spectrum of Extrasolar Planet Reported

This C&EN article summarizes the results of some researchers led by L. Jeremy Richardson, of the Goddard Space Flight Center’s Exoplanets and Stellar Astrophysics Laboratory. They report the the first spectrum of an extrasolar planet, an IR spectrum of a planet transiting HD 209458. It is 150 light years from earth, in the Pegasus constellation, and visible through binoculars. Read the details here.

Sunday, February 25, 2007

C&ENews Comments on Analytical Chemistry Job Market

Focus on Analytical Chemistry Careers
Despite slow hiring, job seekers with top skills and biology background attract recruiters' attention.

Tuesday, January 16, 2007

Data filled Periodic Table

For an interesting web-enabled periodic table, check out: This Link*

*note: you will need the latest version of the shockwave plugin to view. A link to download Shockwave along with a test logo to inform you whether you need it is located on the linked page

Analytical Sciences Shared Feed Results

Many of the shared feed links below require access to Engineering Village.